Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287532 | 0.85 | PDE11A (0.51) | PDE11AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8286086 | 0.85 | PDE11A (0.46) | PDE11AKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8286558 | 0.84 | PDE11A (0.46) | PDE11AKDM4EALDH1A1HPGDPKM | |
| SCHEMBL8285339 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1HPGDTP53L3MBTL1 | |
| SCHEMBL8285337 | 0.83 | HSP90AA1 (0.47) | PDE11AKDM4EALDH1A1HPGDPKM | |
| SCHEMBL8286426 | 0.81 | PDE11A (0.39) | PDE11AKDM4EALDH1A1HPGDTP53 | |
| SCHEMBL8286076 | 0.80 | PDE11A (0.39) | PDE11AKDM4EALDH1A1HPGDTP53 | |
| SCHEMBL8286083 | 0.79 | PDE11A (0.38) | PDE11AKDM4EALDH1A1HPGDTP53 | |
| SCHEMBL8287237 | 0.79 | PDE11A (0.43) | PDE11AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8287403 | 0.79 | PDE11A (0.56) | PDE11AKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |