Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872104 | 0.86 | GAA (0.45) | SMN1; SMN2KMT2APDE11APOLBGAA | |
| SCHEMBL8287419 | 0.85 | PDE11A (0.51) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8286558 | 0.84 | PDE11A (0.46) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8286548 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2AMAPTTSHRPOLB | |
| SCHEMBL8285340 | 0.83 | PDE11A (0.45) | ALDH1A1SMN1; SMN2PDE11AMAPTGAA | |
| SCHEMBL8286039 | 0.82 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL5872280 | 0.81 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL7036674 | 0.81 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2PDE11AMAPTGAA | |
| SCHEMBL8287221 | 0.79 | APLNR (0.42) | ALDH1A1SMN1; SMN2PDE11AMAPTTSHR | |
| SCHEMBL8287403 | 0.79 | PDE11A (0.56) | ALDH1A1SMN1; SMN2PDE11AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |