Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286461 | 0.93 | PDE11A (0.47) | PDE11AIGF1RMAPTMAPK1MAT2A | |
| SCHEMBL8287408 | 0.90 | PDE11A (0.44) | PDE11AMAPTMAPK1MAT2AALDH1A1 | |
| SCHEMBL8287461 | 0.89 | MAT2A (0.44) | PDE11AMAPTMAPK1MAT2AL3MBTL1 | |
| SCHEMBL8287925 | 0.86 | PDE11A (0.42) | PDE11AMAPTMAPK1ALDH1A1HPGD | |
| SCHEMBL8287935 | 0.85 | NCF1 (0.43) | PDE11AMAPTMAPK1ALDH1A1KDM4E | |
| SCHEMBL8286539 | 0.84 | PDE11A (0.42) | PDE11AMAPTMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL8287402 | 0.82 | PDE11A (0.39) | PDE11AMAT2ALMNA | |
| SCHEMBL8287910 | 0.82 | MAPT (0.43) | PDE11AMAPTMAPK1TP53L3MBTL1 | |
| SCHEMBL8287829 | 0.82 | PDE11A (0.64) | PDE11AIGF1RMAPTMAPK1TP53 | |
| SCHEMBL8286167 | 0.82 | DRD2 (0.39) | PDE11AMAPTMAPK1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |