Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 2/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286174 | 0.89 | BRAF (0.39) | ALDH1A1SMN1; SMN2TSHRGAAHPGD | |
| SCHEMBL8287246 | 0.86 | GAA (0.39) | ALDH1A1RECQLSMN1; SMN2GAAHPGD | |
| SCHEMBL8286178 | 0.84 | GAA (0.36) | ALDH1A1SMN1; SMN2GAAHPGDMAPK1 | |
| SCHEMBL8287590 | 0.84 | CSF1R (0.35) | KCNJ6KCNJ5KCNJ3TSHRGAA | |
| SCHEMBL8286173 | 0.82 | GAA (0.36) | ALDH1A1SMN1; SMN2TSHRGAAHPGD | |
| SCHEMBL8286211 | 0.82 | MAP3K8 (0.34) | GAAHPGDMAPK1GFERMAPT | |
| SCHEMBL8286182 | 0.82 | MAT2A (0.46) | ALDH1A1SMN1; SMN2GAAHPGDMAPK1 | |
| SCHEMBL8287991 | 0.81 | GAA (0.39) | ALDH1A1SMN1; SMN2GAAHPGDMAPK1 | |
| SCHEMBL8287214 | 0.81 | GAA (0.44) | KCNJ6KCNJ5KCNJ3ALDH1A1RECQL | |
| SCHEMBL8360854 | 0.81 | MAPK14 (0.38) | ALDH1A1SMN1; SMN2GAAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |