Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286178 | 0.90 | GAA (0.36) | GAAALDH1A1SMN1; SMN2CSF1RCDK4 | |
| SCHEMBL8286211 | 0.88 | MAP3K8 (0.34) | GAACSF1RCDK4CCND1CCND2 | |
| SCHEMBL8286182 | 0.87 | MAT2A (0.46) | GAAALDH1A1SMN1; SMN2CSF1RHPGD | |
| SCHEMBL8286174 | 0.84 | BRAF (0.39) | GAAALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL8287246 | 0.84 | GAA (0.39) | GAAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8287276 | 0.83 | MAT2A (0.40) | GAASMN1; SMN2HPGDMAPK1KDM4E | |
| SCHEMBL8287263 | 0.83 | TSHR (0.40) | GAAALDH1A1L3MBTL1TSHRMEN1 | |
| SCHEMBL8286184 | 0.83 | ALDH1A1 (0.39) | GAAALDH1A1KMT2APOLBMAPT | |
| SCHEMBL8285367 | 0.82 | KCNJ6 (0.37) | GAAALDH1A1TSHRSMN1; SMN2HPGD | |
| SCHEMBL8287280 | 0.82 | RAB9A (0.43) | GAAALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |