Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 3/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | TAF1 | P21675 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287461 | 0.87 | MAT2A (0.44) | PDE11AMAT2A | |
| SCHEMBL8286461 | 0.87 | PDE11A (0.47) | PDE11ADRD2DRD4DRD3MAT2A | |
| SCHEMBL8286097 | 0.84 | PDE11A (0.45) | PDE11AHTR7DRD2DRD4DRD3 | |
| SCHEMBL8287408 | 0.84 | PDE11A (0.44) | PDE11AMAT2A | |
| SCHEMBL8287925 | 0.83 | PDE11A (0.42) | PDE11ALMNAPOLBJAK2BRD4 | |
| SCHEMBL8287403 | 0.82 | PDE11A (0.56) | PDE11AMAT2ALMNA | |
| SCHEMBL8287935 | 0.82 | NCF1 (0.43) | PDE11ALMNAGFER | |
| SCHEMBL8287910 | 0.81 | MAPT (0.43) | PDE11AP2RY12POLB | |
| SCHEMBL8286167 | 0.80 | DRD2 (0.39) | PDE11ADRD2DRD3P2RY12POLB | |
| SCHEMBL8286189 | 0.77 | PDE11A (0.39) | PDE11AMAT2ALMNAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |