Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SHBG | P04278 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285975 | 0.85 | KMT2A (0.38) | RAB9AMEN1KMT2ANPC1HSP90AA1 | |
| SCHEMBL16953354 | 0.83 | NQO1 (0.48) | RAB9AMEN1KMT2ANPC1TDP1 | |
| SCHEMBL9923804 | 0.80 | FYN (0.39) | RAB9ASHBGMEN1KMT2AMAOB | |
| SCHEMBL6123753 | 0.79 | KDM4E (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23712909 | 0.77 | TSHR (0.42) | RAB9AMAOBNPC1HSP90AA1TDP1 | |
| SCHEMBL16319058 | 0.76 | ALOX5 (0.53) | RAB9AMEN1KMT2AMAOBNPC1 | |
| SCHEMBL2199273 | 0.75 | APP (0.50) | RAB9AMEN1KMT2AMAOBNPC1 | |
| SCHEMBL31470219 | 0.74 | SHBG (0.35) | SHBGMEN1KMT2AMAOBSMN1; SMN2 | |
| SCHEMBL19454753 | 0.74 | KMT2A (0.49) | MEN1KMT2ANPC1TDP1L3MBTL1 | |
| SCHEMBL20439168 | 0.73 | LTA4H (0.53) | RAB9AMEN1KMT2ANPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058857-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |