Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.34 |
| ▸ | RHOA | P61586 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287259 | 0.92 | GAA (0.34) | PLA2G4AGSK3BGAAPDE11AGFER | |
| SCHEMBL8287273 | 0.92 | PDE11A (0.34) | PLA2G4AGAAPDE11AGFERHPGD | |
| SCHEMBL8287270 | 0.91 | HSD11B1 (0.40) | GSK3AGSK3BGAAPDE11AGFER | |
| SCHEMBL8286560 | 0.91 | MAPT (0.39) | GAANPC1HPGD | |
| SCHEMBL8286552 | 0.90 | CCNC (0.37) | GAAPDE11AGFERRAB9AHPGD | |
| SCHEMBL8287263 | 0.90 | TSHR (0.40) | GSK3AGSK3BGAAPDE11AGFER | |
| SCHEMBL8286557 | 0.87 | NPC1 (0.40) | GAAPDE11ANPC1RAB9AFFAR1 | |
| SCHEMBL8286554 | 0.87 | ALDH1A1 (0.35) | PLA2G4AGSK3BGAAPDE11AEGLN1 | |
| SCHEMBL8286175 | 0.87 | GAA (0.36) | GSK3BGAAPDE11AGFERHPGD | |
| SCHEMBL8287262 | 0.86 | HSD11B1 (0.46) | PDE11AHPGDCDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |