Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CCKAR | P32238 | 1/20 | 0.31 |
| ▸ | CCKBR | P32239 | 1/20 | 0.31 |
| ▸ | MARK3 | P27448 | 1/20 | 0.31 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.31 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | CDK4 | P11802 | 2/20 | 0.31 |
| ▸ | CCND1 | P24385 | 2/20 | 0.31 |
| ▸ | CCND2 | P30279 | 2/20 | 0.31 |
| ▸ | CCND3 | P30281 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286455 | 0.86 | PLA2G4A (0.37) | PDE11AHPGDCDK4CCND1CCND2 | |
| SCHEMBL8287273 | 0.84 | PDE11A (0.34) | PDE11AHPGDALDH1A1KDM4EHTT | |
| SCHEMBL8287259 | 0.84 | GAA (0.34) | HSD11B1PDE11AHPGDALDH1A1KDM4E | |
| SCHEMBL8286557 | 0.84 | NPC1 (0.40) | PDE11AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8286568 | 0.83 | BACE1 (0.38) | PDE11AHPGDALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8286560 | 0.83 | MAPT (0.39) | HPGDALDH1A1KDM4EHTTMAPT | |
| SCHEMBL8287270 | 0.83 | HSD11B1 (0.40) | HSD11B1PDE11AMAPTSMN1; SMN2 | |
| SCHEMBL8287264 | 0.83 | PDE11A (0.31) | PDE11A | |
| SCHEMBL8286552 | 0.82 | CCNC (0.37) | PDE11AHPGDALDH1A1KDM4EMEN1 | |
| SCHEMBL8287263 | 0.82 | TSHR (0.40) | PDE11AHPGDALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |