Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286455 | 0.87 | PLA2G4A (0.37) | NPC1PDE11AFFAR1RAB9AGAA | |
| SCHEMBL8287273 | 0.85 | PDE11A (0.34) | ALDH1A1PDE11AKDM4EGAA | |
| SCHEMBL8287259 | 0.85 | GAA (0.34) | KMT2AALDH1A1PDE11AMEN1MAPT | |
| SCHEMBL8286560 | 0.85 | MAPT (0.39) | NPC1ALDH1A1TP53MAPTKDM4E | |
| SCHEMBL8287270 | 0.85 | HSD11B1 (0.40) | PDE11AMAPTGAA | |
| SCHEMBL8286552 | 0.84 | CCNC (0.37) | KMT2AALDH1A1PDE11AMEN1RAB9A | |
| SCHEMBL8287263 | 0.84 | TSHR (0.40) | TDP1KMT2AALDH1A1PDE11AMEN1 | |
| SCHEMBL8287262 | 0.84 | HSD11B1 (0.46) | KMT2AALDH1A1PDE11AMEN1MAPT | |
| SCHEMBL8286184 | 0.83 | ALDH1A1 (0.39) | KMT2AALDH1A1GRM5RAB9ATP53 | |
| SCHEMBL8286554 | 0.81 | ALDH1A1 (0.35) | KMT2AALDH1A1PDE11AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |