Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286429 | 0.92 | MAT2A (0.39) | MAT2AHTTKDM4EPDE11ACSF1R | |
| SCHEMBL8287487 | 0.90 | PDE11A (0.38) | MAT2AHTTKDM4EPDE11ACSF1R | |
| SCHEMBL8287436 | 0.89 | PDE11A (0.37) | MAT2AHTTKDM4EPDE11ACSF1R | |
| SCHEMBL8287555 | 0.88 | KDM4E (0.36) | MAT2AHTTKDM4EPDE11ACSF1R | |
| SCHEMBL8362883 | 0.88 | OPRK1 (0.39) | MAT2AHTTKDM4EPDE11ACSF1R | |
| SCHEMBL8286432 | 0.84 | KMT2A (0.39) | KDM4EPDE11AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8287451 | 0.84 | PDE11A (0.42) | MAT2AHTTKDM4EPDE11AGAA | |
| SCHEMBL8287426 | 0.83 | CYP3A4 (0.42) | MAT2AHTTKDM4EPDE11AMAPK1 | |
| SCHEMBL8285208 | 0.83 | MAT2A (0.38) | MAT2AHTTKDM4EPDE11ACSF1R | |
| SCHEMBL8287433 | 0.82 | RAB9A (0.38) | HTTKDM4EPDE11ACSF1RGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |