Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 7/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287593 | 0.92 | GSK3B (0.37) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8286468 | 0.90 | GSK3B (0.38) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287526 | 0.89 | MAPK13 (0.38) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8286472 | 0.89 | EGFR (0.46) | LCKEGFR | |
| SCHEMBL8362924 | 0.87 | GSK3B (0.39) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287920 | 0.87 | CSF1R (0.37) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8285291 | 0.86 | GABRA1 (0.40) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287936 | 0.85 | RIPK1 (0.40) | GSK3BPDE11ALCKEGFR | |
| SCHEMBL8287197 | 0.84 | EGFR (0.43) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287486 | 0.84 | LMNA (0.37) | GSK3BCDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |