Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287312 | 0.86 | AKR1C3 (0.51) | ALDH1A1PRMT1AKR1C3KMT2AMAPK1 | |
| SCHEMBL8288311 | 0.86 | TAAR1 (0.59) | ALDH1A1TAAR1KMT2ATDP1CA1 | |
| SCHEMBL8289277 | 0.86 | ALDH1A1 (0.57) | ALDH1A1PRMT1TAAR1AKR1C3KMT2A | |
| SCHEMBL13612187 | 0.84 | ALDH1A1 (0.42) | ALDH1A1PRMT1TAAR1AKR1C3KMT2A | |
| SCHEMBL8289264 | 0.84 | LSS (0.43) | ALDH1A1PRMT1AKR1C3KMT2AMAPK1 | |
| SCHEMBL13604124 | 0.83 | CA1 (0.47) | ALDH1A1PRMT1TAAR1AKR1C3KMT2A | |
| SCHEMBL8288351 | 0.79 | TP53 (0.42) | ALDH1A1TAAR1KMT2ACA1CA2 | |
| SCHEMBL8287311 | 0.79 | ALDH1A1 (0.68) | ALDH1A1AKR1C3KMT2ACA1CA2 | |
| SCHEMBL13611732 | 0.79 | MEN1 (0.60) | ALDH1A1PRMT1AKR1C3KMT2ACA1 | |
| SCHEMBL8288312 | 0.76 | LSS (0.56) | ALDH1A1TAAR1KMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |