Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NSD2 | O96028 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288313 | 0.86 | CA1 (0.42) | ALDH1A1NSD2SMN1; SMN2KMT2ACA1 | |
| SCHEMBL13611592 | 0.84 | TP53 (0.40) | TP53TAAR1ALDH1A1NSD2TSHR | |
| SCHEMBL8288305 | 0.83 | SMN1; SMN2 (0.39) | ALDH1A1NSD2SMN1; SMN2KMT2ACA1 | |
| SCHEMBL8289277 | 0.83 | ALDH1A1 (0.57) | TAAR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13604122 | 0.82 | LPL (0.47) | TP53TAAR1ALDH1A1TSHRGRIA4 | |
| SCHEMBL8288311 | 0.81 | TAAR1 (0.59) | TAAR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8288343 | 0.79 | ALDH1A1 (0.45) | TAAR1ALDH1A1GBA1KMT2ACA1 | |
| SCHEMBL8289308 | 0.76 | PKM (0.59) | TP53ALDH1A1TSHRHTT | |
| SCHEMBL8287311 | 0.76 | ALDH1A1 (0.68) | TP53ALDH1A1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL13611732 | 0.76 | MEN1 (0.60) | TP53ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |