Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288312 | 0.87 | LSS (0.56) | LSSALDH1A1KMT2ACA1CA2 | |
| SCHEMBL13611590 | 0.85 | ALDH1A1 (0.40) | LSSALDH1A1PRMT1AKR1C3MAPK1 | |
| SCHEMBL8288343 | 0.84 | ALDH1A1 (0.45) | ALDH1A1PRMT1AKR1C3MAPK1KMT2A | |
| SCHEMBL8287312 | 0.84 | AKR1C3 (0.51) | ALDH1A1PRMT1AKR1C3MAPK1KMT2A | |
| SCHEMBL8289277 | 0.83 | ALDH1A1 (0.57) | ALDH1A1PRMT1AKR1C3KMT2ATDP1 | |
| Water SCHEMBL28775032 | 0.79 | ALDH1A1 (0.50) | LSSALDH1A1PRMT1AKR1C3MAPK1 | |
| SCHEMBL3861652 | 0.79 | LSS (0.50) | LSSALDH1A1PRMT1AKR1C3MAPK1 | |
| SCHEMBL8288305 | 0.78 | SMN1; SMN2 (0.39) | LSSALDH1A1KMT2ACA1CA2 | |
| SCHEMBL3861470 | 0.78 | LSS (0.51) | LSSALDH1A1PRMT1AKR1C3MAPK1 | |
| SCHEMBL13611732 | 0.76 | MEN1 (0.60) | LSSALDH1A1PRMT1AKR1C3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |