Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.57 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13837645 | 0.82 | MAPT (0.76) | MAPTALDH1A1HTTCRHBPCRHR2 | |
| SCHEMBL8290370 | 0.81 | MAPT (0.68) | MAPTALDH1A1HTTCRHBPCRHR2 | |
| SCHEMBL5804278 | 0.81 | MAPT (0.73) | MAPTALDH1A1HTTCRHBPCRHR2 | |
| SCHEMBL5804285 | 0.80 | MAPT (0.72) | MAPTALDH1A1HTTCRHBPCRHR2 | |
| SCHEMBL8288714 | 0.77 | PRKCZ (0.81) | MAPTALDH1A1PRKCZHPGDMAPK1 | |
| SCHEMBL7970089 | 0.70 | HTT (0.53) | MAPTALDH1A1HTTCRHBPCRHR2 | |
| SCHEMBL13837727 | 0.68 | PRKCZ (1.00) | MAPTALDH1A1PRKCZHPGDMAPK1 | |
| SCHEMBL1895353 | 0.68 | MEN1 (0.78) | MAPTALDH1A1CRHBPCRHR2HPGD | |
| SCHEMBL10459766 | 0.68 | HTT (0.56) | MAPTALDH1A1HTTPRKCZHPGD | |
| SCHEMBL7980488 | 0.68 | HTT (0.60) | MAPTALDH1A1HTTPRKCZHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |