Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13611591 | 0.85 | SMN1; SMN2 (0.35) | SMN1; SMN2LSSNSD2KMT2AALDH1A1 | |
| SCHEMBL13604119 | 0.83 | CA1 (0.44) | SMN1; SMN2LSSNSD2ALDH1A1CA1 | |
| SCHEMBL8288351 | 0.83 | TP53 (0.42) | SMN1; SMN2NSD2KMT2AALDH1A1CA1 | |
| SCHEMBL8288313 | 0.83 | CA1 (0.42) | SMN1; SMN2NSD2KMT2AALDH1A1CA1 | |
| SCHEMBL8289277 | 0.80 | ALDH1A1 (0.57) | SMN1; SMN2KMT2AALDH1A1CA1CA2 | |
| SCHEMBL8288312 | 0.80 | LSS (0.56) | SMN1; SMN2LSSKMT2AALDH1A1CA1 | |
| SCHEMBL8289264 | 0.78 | LSS (0.43) | LSSKMT2AALDH1A1CA1CA2 | |
| SCHEMBL8289308 | 0.74 | PKM (0.59) | ALDH1A1HTT | |
| SCHEMBL13611732 | 0.73 | MEN1 (0.60) | SMN1; SMN2LSSKMT2AALDH1A1CA1 | |
| SCHEMBL8287311 | 0.73 | ALDH1A1 (0.68) | SMN1; SMN2KMT2AALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |