Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.61 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767883 | 0.90 | MAPT (0.68) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL8289583 | 0.81 | HPGD (0.74) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL15273119 | 0.78 | ALDH1A1 (0.69) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL2775850 | 0.75 | MAPT (0.67) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL29502855 | 0.75 | MAPT (0.67) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL13744490 | 0.75 | RAB9A (0.57) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL8288738 | 0.73 | HPGD (0.74) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| Nitrogen SCHEMBL28918348 | 0.73 | MAPT (0.65) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL31700686 | 0.72 | ALDH1A1 (0.64) | MAPTKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL8289336 | 0.72 | ALDH1A1 (0.76) | RAB9AMAPTKDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |