Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | ESR1 | P03372 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | CASP3 | P42574 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.74 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.74 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.74 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.74 |
| ▸ | CNR2 | P34972 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403591 | 0.85 | NPC1 (1.00) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL15273119 | 0.83 | ALDH1A1 (0.69) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL8289620 | 0.81 | RAB9A (0.67) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL8290510 | 0.81 | MAPT (0.77) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL5449432 | 0.79 | ALDH1A1 (1.00) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL14328953 | 0.79 | MAPT (0.74) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL3916162 | 0.79 | MAPT (0.80) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL13561104 | 0.78 | MAPT (1.00) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL8290769 | 0.77 | MAPT (0.79) | HPGDHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL7892222 | 0.77 | MAPT (0.84) | HPGDHSD17B10KDM4EMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051220-A1 | COMPOUNDS FOR USE IN THERAPY | GLUCOX BIOTECH AB (SE) | 2015-02-19 | — | — | US | disclosed |
| EP-2825165-A1 | THIOPHENE-BASED COMPOUNDS EXHIBITING NOX4 INHIBITORY ACTIVITY AND USE THEREOF IN THERAPY | Glucox Biotech AB (SE) | 2015-01-21 | — | — | EP | disclosed |
| WO-2013135803-A1 | THIOPHENE-BASED COMPOUNDS EXHIBITING NOX4 INHIBITORY ACTIVITY AND USE THEREOF IN THERAPY | GLUCOX BIOTECH AB (SE) | 2013-09-19 | — | — | WO | disclosed |
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051220-A1 | COMPOUNDS FOR USE IN THERAPY | XDH, PNPO, OAT | HPGD 33/4885HSD17B10 301/4885KDM4E 4495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.