Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13438093 | 0.92 | MAPT (0.64) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL8288727 | 0.92 | MAPT (0.64) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL34468504 | 0.84 | ALDH1A1 (0.66) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL34468585 | 0.82 | TNKS2 (0.67) | MAPTTP53KDM4EMAPK1LMNA | |
| SCHEMBL34468610 | 0.81 | TP53 (0.67) | MAPTTP53KDM4EMAPK1LMNA | |
| SCHEMBL8290780 | 0.80 | TP53 (0.60) | MAPTTP53LMNAALDH1A1HPGD | |
| SCHEMBL8288732 | 0.79 | POLB (0.78) | MAPTTP53KDM4EMAPK1LMNA | |
| SCHEMBL8289567 | 0.75 | TP53 (0.72) | MAPTTP53MAPK1LMNAALDH1A1 | |
| SCHEMBL11493125 | 0.75 | ALDH1A1 (0.76) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL34468614 | 0.74 | ALDH1A1 (0.79) | MAPTTP53KDM4EMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |