Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290887 | 0.89 | THRB (0.55) | TP53SMN1; SMN2ANO1HPGDTSHR | |
| SCHEMBL13438093 | 0.88 | MAPT (0.64) | TP53SMN1; SMN2ANO1HPGDALDH1A1 | |
| SCHEMBL8289729 | 0.80 | MAPT (0.67) | TP53SMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL8289567 | 0.78 | TP53 (0.72) | TP53SMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL8288727 | 0.78 | MAPT (0.64) | TP53SMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL31701624 | 0.77 | ALDH1A1 (0.64) | HPGDALDH1A1TSHRPOLBMAPT | |
| SCHEMBL3489776 | 0.77 | ALDH1A1 (0.64) | TP53SMN1; SMN2ANO1HPGDALDH1A1 | |
| SCHEMBL31701007 | 0.76 | ALDH1A1 (0.62) | TP53SMN1; SMN2HPGDALDH1A1POLB | |
| SCHEMBL34468610 | 0.74 | TP53 (0.67) | TP53SMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL31702048 | 0.73 | ALDH1A1 (0.56) | TP53HPGDALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |