Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.57 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL862840 | 0.96 | DNM1 (0.55) | DNM1PAOXTP53SMN1; SMN2KMT2A | |
| SCHEMBL829473 | 0.89 | DNM1 (0.55) | DNM1PAOXTP53SMN1; SMN2HRH3 | |
| SCHEMBL828995 | 0.82 | DRD2 (0.51) | DNM1SIGMAR1 | |
| SCHEMBL10030583 | 0.81 | DNM1 (0.52) | DNM1PAOXTP53SMN1; SMN2KMT2A | |
| SCHEMBL23899001 | 0.81 | DNM1 (0.82) | DNM1PAOX | |
| SCHEMBL8437935 | 0.79 | FAAH (0.55) | DNM1PAOXTP53SMN1; SMN2KMT2A | |
| SCHEMBL7137887 | 0.79 | DNM1 (0.79) | DNM1PAOX | |
| SCHEMBL20998566 | 0.79 | USP2 (0.56) | PAOXTP53SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL22564677 | 0.79 | PAOX (0.59) | PAOXTP53SMN1; SMN2KMT2A | |
| SCHEMBL16353612 | 0.78 | SMN1; SMN2 (0.54) | PAOXTP53SMN1; SMN2KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143256-B2 | 5-(4-{4-[A7-(3,5-diamino-6-chloropyrazine-2 carbonyl)guanadio]butyl}-piperazin-1-yl)pentanoic acid (3-dimethylaminopropyl) amide; hydration of mucosal surfaces; Chronic bronchitis; cystic fibrosis; more potent; absorbed slower; target kidney in treating cardiovascular disease; diuretics | PARION SCIENCES, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143256-B2 | 5-(4-{4-[A7-(3,5-diamino-6-chloropyrazine-2 carbonyl)guanadio]butyl}-piperazin-1-yl)pentanoic acid (3-dimethylaminopropyl) amide; hydration of mucosal surfaces; Chronic bronchitis; cystic fibrosis; more potent; absorbed slower; target kidney in treating cardiovascular disease; diuretics | PARION SCIENCES, INC. (US) | 2012-03-27 | — | — | US | disclosed |