Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.72 |
| ▸ | HPGD | P15428 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289821 | 0.85 | MAPT (0.76) | ALDH1A1KDM4ERAB9ANPC1MAPT | |
| SCHEMBL4145641 | 0.83 | MAPT (0.82) | ALDH1A1KDM4ERAB9AHPGDNPC1 | |
| SCHEMBL21346802 | 0.82 | MAPT (1.00) | ALDH1A1KDM4ERAB9AHPGDNPC1 | |
| SCHEMBL21347427 | 0.82 | MAPT (1.00) | ALDH1A1KDM4ERAB9AHPGDNPC1 | |
| SCHEMBL21347434 | 0.82 | ALDH1A1 (0.62) | ALDH1A1KDM4ERAB9AHPGDNPC1 | |
| SCHEMBL5454136 | 0.80 | REV1 (0.81) | ALDH1A1KDM4ERAB9AHPGDNPC1 | |
| SCHEMBL21346848 | 0.79 | PDE4B (0.68) | ALDH1A1KDM4ERAB9AHPGDNPC1 | |
| SCHEMBL1066142 | 0.78 | FLT3 (0.68) | ALDH1A1KDM4ERAB9AHPGDNPC1 | |
| SCHEMBL5457818 | 0.78 | FLT3 (1.00) | ALDH1A1RAB9ANPC1MAPTKMT2A | |
| SCHEMBL16596087 | 0.76 | REV1 (0.62) | ALDH1A1KDM4ERAB9AHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |