Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | XBP1 | P17861 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.62 |
| ▸ | AIP | O00170 | 1/20 | 0.62 |
| ▸ | SGTA | O43765 | 1/20 | 0.62 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290603 | 0.78 | ALDH1A1 (0.72) | FLT3KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL5451446 | 0.76 | AIP (0.71) | FLT3KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL5453282 | 0.76 | AIP (0.71) | FLT3KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL21247230 | 0.75 | THRB (0.79) | FLT3KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL21247250 | 0.75 | THRB (0.68) | FLT3KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL5460515 | 0.75 | AIP (0.69) | KDM4EALDH1A1RAB9AMAPTKMT2A | |
| SCHEMBL23657531 | 0.74 | ALDH1A1 (0.69) | KDM4EALDH1A1RAB9AMAPTKMT2A | |
| SCHEMBL5453529 | 0.74 | TNIK (0.59) | FLT3MAPTTNIK | |
| SCHEMBL2182372 | 0.74 | TP53 (0.80) | FLT3KDM4EALDH1A1RAB9AMAPT | |
| SCHEMBL1067537 | 0.73 | ALDH1A1 (0.80) | KDM4EALDH1A1RAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222326-B2 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | VIB VZW (BE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2222326-B1 | Inhibitors of MALT1-proteolytic activity and uses thereof | VIB VZW (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | MMEL1, CTRL, ZFR | FLT3 4205/4885KDM4E 566/4885ALDH1A1 4353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.