Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3774073 | 0.84 | MAPT (0.44) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL3774071 | 0.84 | MAPT (0.44) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL5003789 | 0.76 | CTSS (0.44) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL836552 | 0.71 | CTSK (0.65) | CTSSCTSKCTSLCTSBCAPN1 | |
| SCHEMBL15511095 | 0.71 | CYP2D6 (0.54) | CTSSCTSKMMEACECPA1 | |
| SCHEMBL27047731 | 0.70 | CYP2D6 (0.33) | MMEACECPA1ACE2CYP2D6 | |
| SCHEMBL2332543 | 0.69 | — | — | |
| SCHEMBL22311455 | 0.69 | — | — | |
| Bicarbonate SCHEMBL9087678 | 0.69 | CA2 (0.33) | MMEACECPA1ACE2MAPT | |
| SCHEMBL18769148 | 0.69 | ALDH1A1 (0.31) | MMEACECPA1ACE2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143375-B2 | Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes for their preparation | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-03-27 | — | — | US | disclosed |