SCHEMBL8295663

SCHEMBL8295663

CCOC(=O)C(Cc1ccccc1)c1nc(-c2ccc(F)cc2)c(-c2ccc([S+](C)[O-])cc2)o1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.39
PTGS2 P35354 4/20 0.39
NR4A2 P43354 4/20 0.38
RXRA P19793 3/20 0.36
RXRB P28702 2/20 0.36
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
CYP1A2 P05177 1/20 0.36
POLB P06746 1/20 0.36
HSP90AA1 P07900 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
HTT P42858 1/20 0.36
CCR6 P51684 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL216120 0.86 PTGS2 (0.53) PTGS2PTGS1
SCHEMBL7504823 0.86 PTGS2 (0.53) KMT2APTGS2SMN1; SMN2NPSR1PTGS1
SCHEMBL8289361 0.85 MAPK14 (0.44) KMT2APTGS2NR4A2RXRARXRB
SCHEMBL8549078 0.76 PTGS2 (0.40) KMT2APTGS2NR4A2RXRARXRB
SCHEMBL5089153 0.76 PTGS2 (0.55) PTGS2NR4A2PTGS1
SCHEMBL7501957 0.74 PTGS2 (0.54) PTGS2NR4A2RXRAHPGDSMN1; SMN2
SCHEMBL17896435 0.73 FABP4 (0.54) KMT2AHPGDCYP1A2CYP3A4CYP2D6
SCHEMBL17896439 0.73 PTGIR (0.47) KMT2ANR4A2RXRAHPGDCYP1A2
SCHEMBL27506688 0.71 PTGS2 (0.49) PTGS2PTGS1
SCHEMBL9455596 0.71 PTGIR (0.45) KMT2ARXRARXRBHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005018569-A2 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A SEROTONIN MODULATING AGENT FOR THE TREATMENT OF NEOPLASIA PHARMACIA CORPORATION (US) 2005-03-03 WO disclosed
WO-2005009354-A2 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND AN IKK INHIBITOR FOR THE TREATMENT OF ISCHEMIC-MEDIATED CENTRAL NERVOUS SYSTEM DISORDERS OR INJURY PHARMACIA CORPORATION (US) 2005-02-03 WO disclosed
WO-2005007156-A1 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE PHARMACIA CORPORATION (US) 2005-01-27 WO disclosed
WO-2004093811-A2 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A SODIUM ION CHANNEL BLOCKER FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE PHARMACIA CORPORATION (US) 2004-11-04 WO disclosed