Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462222 | 0.83 | HTT (0.57) | HTTSMN1; SMN2ALOX12ALDH1A1POLB | |
| SCHEMBL8644189 | 0.81 | TSHR (0.58) | HTTSMN1; SMN2ALOX12ALDH1A1POLB | |
| SCHEMBL8145665 | 0.80 | HDAC2 (0.62) | HTTSMN1; SMN2ALDH1A1POLBHDAC8 | |
| SCHEMBL8296171 | 0.79 | HDAC2 (0.64) | HTTSMN1; SMN2ALDH1A1HDAC8HDAC3 | |
| SCHEMBL8296679 | 0.77 | HDAC8 (0.47) | HTTSMN1; SMN2HDAC8HDAC3HDAC6 | |
| SCHEMBL21755154 | 0.76 | POLB (0.57) | HTTSMN1; SMN2ALOX12ALDH1A1POLB | |
| SCHEMBL8296136 | 0.76 | LMNA (0.57) | POLBHDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL13175364 | 0.75 | LMNA (0.60) | POLBHDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL7418597 | 0.74 | POLB (0.55) | HTTSMN1; SMN2ALOX12ALDH1A1POLB | |
| SCHEMBL22610225 | 0.74 | HDAC3 (0.73) | HTTSMN1; SMN2ALOX12ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322160-A1 | Methods of inducing terminal differentiation | Merck HDAC Research, LLC (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-2266552-A2 | Methods of inducing terminal differentiation | Merck HDAC Research, LLC (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-2226072-A1 | Combinations of suberoylanilide hydroxamic acid and antimetbolic agents for treating cancer | Aton Pharma, Inc. (US) | 2010-09-08 | — | — | EP | disclosed |
| EP-2082737-A2 | Methods of inducing terminal differentiation | Merck HDAC Research, LLC (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2005023179-A2 | COMBINATION METHODS OF TREATING CANCER | ATON PHARMA, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| WO-2003075839-A2 | METHODS OF INDUCING TERMINAL DIFFERENTIATION | ATON PHARMA, INC. (US) | 2003-09-18 | — | — | WO | disclosed |