Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462222 | 0.84 | HTT (0.57) | ALOX12SMN1; SMN2HTTALDH1A1MAPK1 | |
| SCHEMBL21755154 | 0.83 | POLB (0.57) | ALOX12SMN1; SMN2HTTALDH1A1POLB | |
| SCHEMBL8296133 | 0.81 | HTT (0.53) | ALOX12SMN1; SMN2HTTALDH1A1POLB | |
| SCHEMBL10290433 | 0.80 | HPGD (0.55) | TSHRSMN1; SMN2HTTALDH1A1MEN1 | |
| SCHEMBL29269298 | 0.79 | MEN1 (0.79) | SMN1; SMN2HTTALDH1A1MEN1MAPT | |
| SCHEMBL29269467 | 0.79 | MEN1 (0.79) | SMN1; SMN2HTTALDH1A1MEN1MAPT | |
| SCHEMBL16289643 | 0.79 | MEN1 (0.79) | SMN1; SMN2HTTALDH1A1MEN1MAPT | |
| SCHEMBL10670094 | 0.79 | MMP2 (0.46) | TSHRSMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL10666796 | 0.79 | MMP2 (0.46) | TSHRSMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL11518363 | 0.77 | MEN1 (0.81) | SMN1; SMN2HTTALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710159-A | IMIDAZOLIN-2-YLAMINOPROPOXY)ISOXAZOL-5-CARBONYLAMINO-2 -BENZYLOXYCARBONYLAMINOPROPIONIC ACID AS ANTIINFLAMMATORY AGENTS, BONE DEGRADATION, TUMORS, METASTASES AND THROMBOSIS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-01-20 | — | — | US | disclosed |