Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 6/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297783 | 0.90 | MME (0.44) | ROCK2ROCK1LMNAMMEGAA | |
| SCHEMBL14519573 | 0.88 | ROCK2 (0.49) | ROCK2ROCK1MMEMCHR1CASR | |
| SCHEMBL8297911 | 0.88 | ROCK2 (0.49) | ROCK2ROCK1MMEMCHR1CASR | |
| SCHEMBL14519491 | 0.86 | MME (0.41) | ROCK2ROCK1LMNAMMEGAA | |
| SCHEMBL8297654 | 0.86 | ALDH1A1 (0.51) | ROCK2ROCK1LMNAMMEGAA | |
| SCHEMBL14543614 | 0.86 | ROCK2 (0.51) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL8297668 | 0.86 | ROCK2 (0.53) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL14519532 | 0.85 | ROCK2 (0.50) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL8297639 | 0.85 | ROCK2 (0.54) | ROCK2ROCK1MMECASRFPR2 | |
| SCHEMBL8295559 | 0.85 | ROCK2 (0.54) | ROCK2ROCK1MMECASRFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202269-B2 | GlyT2 modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |
| WO-2005044810-A1 | GLYT2 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-19 | — | — | WO | disclosed |