Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296137 | 0.90 | ROCK2 (0.49) | MMEGAALMNATDP1MCHR1 | |
| SCHEMBL14543798 | 0.90 | MME (0.46) | MMEMCHR1L3MBTL1ROCK2ROCK1 | |
| SCHEMBL14519491 | 0.85 | MME (0.41) | MMEGAALMNATDP1MCHR1 | |
| SCHEMBL8297036 | 0.85 | MME (0.48) | MMEROCK2ROCK1ITGB3ITGA2B | |
| SCHEMBL8296117 | 0.80 | HTR3A (0.47) | MMELMNAMCHR1GLSALDH1A1 | |
| SCHEMBL8295548 | 0.80 | HTR3A (0.47) | MMELMNAMCHR1GLSALDH1A1 | |
| SCHEMBL14543692 | 0.80 | HTR3A (0.47) | MMELMNAMCHR1GLSALDH1A1 | |
| SCHEMBL14519573 | 0.79 | ROCK2 (0.49) | MMEMCHR1ROCK2ROCK1MMP8 | |
| SCHEMBL8297911 | 0.79 | ROCK2 (0.49) | MMEMCHR1ROCK2ROCK1MMP8 | |
| SCHEMBL5407052 | 0.77 | LMNA (0.56) | LMNAMCHR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044810-A1 | GLYT2 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-19 | — | — | WO | disclosed |