Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 16/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389338 | 0.87 | VCAM1 (0.56) | VCAM1ALDH1A1KDM4EPOLB | |
| SCHEMBL18480794 | 0.84 | CA12 (0.53) | ALDH1A1KDM4EPOLB | |
| SCHEMBL2338516 | 0.81 | HSD11B1 (0.45) | — | |
| SCHEMBL498467 | 0.80 | ALDH1A1 (0.52) | ALDH1A1 | |
| SCHEMBL2651409 | 0.79 | VCAM1 (0.56) | VCAM1ALDH1A1KDM4EPOLBAKR1B10 | |
| SCHEMBL1865348 | 0.79 | VCAM1 (0.56) | VCAM1ALDH1A1KDM4EPOLBAKR1B10 | |
| SCHEMBL6781842 | 0.79 | VCAM1 (0.54) | VCAM1ALDH1A1KDM4EPOLB | |
| SCHEMBL831223 | 0.77 | MMP12 (0.39) | ALDH1A1KDM4EPOLB | |
| SCHEMBL8781357 | 0.77 | VCAM1 (0.53) | VCAM1ALDH1A1KDM4EPOLBAKR1B10 | |
| SCHEMBL3166376 | 0.76 | HSD11B1 (0.50) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143428-B2 | Heteroaryl sulfones and sulfonamides and therapeutic uses thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20070232649-A1 | Heteroaryl Sulfones and Sulfonamides and Therapeutic Uses Thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232649-A1 | Heteroaryl Sulfones and Sulfonamides and Therapeutic Uses Thereof | SULT1E1, STS, CCNE1 | VCAM1 3903/4885ALDH1A1 1141/4885KDM4E 1593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.