Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL830231 | 0.96 | AURKA (0.40) | AURKAHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL829249 | 0.82 | RAB9A (0.41) | HDAC6HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL829800 | 0.80 | ALDH1A1 (0.41) | KMOALDH1A1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL829027 | 0.79 | RAB9A (0.41) | HDAC6HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL2396462 | 0.78 | RAB9A (0.46) | HCAR3ALDH1A1HTTKDM4EGLA | |
| SCHEMBL830054 | 0.77 | HDAC6 (0.39) | HDAC6HDAC3HDAC1HDAC2HCAR3 | |
| SCHEMBL828937 | 0.76 | ALDH1A1 (0.48) | KMOALDH1A1HTTKDM4EKMT2A | |
| SCHEMBL830021 | 0.76 | KMO (0.42) | KMOALDH1A1HTTKDM4EKMT2A | |
| SCHEMBL830028 | 0.74 | KDM4E (0.44) | HDAC6HDAC3HDAC1HDAC2KMO | |
| SCHEMBL2393099 | 0.74 | P4HTM (0.55) | ALDH1A1HTTKDM4EGLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143260-B2 | Tricyclic amine compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-03-27 | — | — | US | disclosed |
| US-8143260-B2 | Tricyclic amine compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-03-27 | — | — | US | disclosed |
| US-20110288299-A1 | TRICYCLIC AMINE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-11-24 | — | — | US | disclosed |
| US-20110288299-A1 | TRICYCLIC AMINE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-11-24 | — | — | US | disclosed |
| EP-2189440-A1 | TRICYCLIC AMINE COMPOUND | Research Foundation Itsuu Laboratory (JP) | 2010-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288299-A1 | TRICYCLIC AMINE COMPOUND | RXRA, RXRB, NR2C2 | AURKA 2353/4885HDAC6 636/4885HDAC3 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.