SCHEMBL8297064

SCHEMBL8297064

CC1=C(C#N)C(c2ccccc2Cl)C(C(=O)OCCC#N)=C(C)N1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.53
CACNA1C Q13936 4/20 0.51
HSD17B10 Q99714 3/20 0.51
NR3C2 P08235 2/20 0.51
MAPT P10636 2/20 0.51
HPGD P15428 2/20 0.51
TSHR P16473 2/20 0.51
ALOX15 P16050 1/20 0.51
CASP1 P29466 1/20 0.51
CASP7 P55210 1/20 0.51
CYP2C9 P11712 3/20 0.47
TBXA2R P21731 3/20 0.47
ADRA1A P35348 3/20 0.47
SLC6A3 Q01959 3/20 0.47
KDM4E B2RXH2 2/20 0.47
MEN1 O00255 2/20 0.47
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2C19 P33261 2/20 0.47
KMT2A Q03164 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10747172 0.89 ALDH1A1 (0.55) ALDH1A1CACNA1CHSD17B10NR3C2MAPT
SCHEMBL10894470 0.89 CACNA1C (0.62) ALDH1A1CACNA1CHSD17B10NR3C2MAPT
SCHEMBL8518663 0.88 ABCB11 (0.61) ALDH1A1CACNA1CHSD17B10MAPTHPGD
SCHEMBL10782866 0.85 ALDH1A1 (0.46) ALDH1A1CACNA1CHSD17B10NR3C2MAPT
SCHEMBL10892959 0.85 CACNA1C (0.53) ALDH1A1CACNA1CHSD17B10NR3C2MAPT
SCHEMBL10897319 0.85 HTR1A (0.49) ALDH1A1CACNA1CHSD17B10NR3C2MAPT
SCHEMBL8297431 0.84 ALDH1A1 (0.58) ALDH1A1CACNA1CHSD17B10NR3C2MAPT
SCHEMBL10895683 0.84 MAPT (0.59) ALDH1A1CACNA1CHSD17B10NR3C2MAPT
SCHEMBL8298008 0.83 TBXA2R (0.47) ALDH1A1CACNA1CHSD17B10MAPTHPGD
SCHEMBL15026460 0.82 ALDH1A1 (0.52) ALDH1A1CACNA1CHSD17B10MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005016885-A2 COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE ARTESIAN THERAPEUTICS, INC. (US) 2005-02-24 WO disclosed
US-4568681-A Antihypertensive tetrahydropyridine 3,5 dicarboxylic acid esters BAYER AKTIENGESELLSCHAFT (DE) 1986-02-04 US disclosed
US-4559350-A Antihypertensive tetrahydropyridine 3-cyano 5-carboxylic acid esters BAYER AKTIENGESELLSCHAFT (DE) 1985-12-17 US disclosed