Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.49 |
| ▸ | MEF2D | Q14814 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL830001 | 0.88 | EHMT2 (0.50) | HSD17B10EHMT2ALDH1A1 | |
| SCHEMBL829775 | 0.88 | EHMT2 (0.54) | HSD17B10EHMT2HDAC4MEF2DCTSK | |
| SCHEMBL830564 | 0.80 | HDAC3 (0.46) | EHMT2HDAC4ALDH1A1HPGDHDAC3 | |
| SCHEMBL10308272 | 0.79 | EHMT2 (0.49) | EHMT2HDAC4MEF2DHPGDCTSK | |
| SCHEMBL829136 | 0.76 | CTSK (0.58) | EHMT2HDAC4MEF2DCTSKLMNA | |
| SCHEMBL830075 | 0.74 | EHMT2 (0.52) | EHMT2ALDH1A1 | |
| SCHEMBL829138 | 0.73 | LMNA (0.58) | CTSKLMNAPOLBTRPV1HTT | |
| SCHEMBL828397 | 0.70 | MMP1 (0.56) | EHMT2HDAC4HDAC3HDAC1HDAC7 | |
| SCHEMBL21755225 | 0.70 | LMNA (0.56) | LMNAPOLBHDAC1TRPV1HTT | |
| SCHEMBL23454666 | 0.70 | MEN1 (0.58) | HSD17B10EHMT2HDAC4ALDH1A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178783-A1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY, INC. | 2012-07-12 | — | — | US | disclosed |
| US-8143445-B2 | HDAC inhibitors | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| WO-2009045440-A1 | HDAC INHIBITORS | LIXTE BIOTECHNOLOGY HOLDINGS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178783-A1 | HDAC INHIBITORS | HDAC3, HDAC4, HDAC7 | HSD17B10 604/4885EHMT2 88/4885HDAC4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.