Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 0.43 |
| ▸ | MMP3 | P08254 | 10/20 | 0.43 |
| ▸ | MMP1 | P03956 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297616 | 1.00 | MMP2 (0.43) | MMP2MMP3MMP1LMNATSHR | |
| SCHEMBL1609320 | 0.93 | MMP2 (0.51) | MMP2MMP3MMP1LMNATSHR | |
| SCHEMBL1610156 | 0.93 | MMP2 (0.51) | MMP2MMP3MMP1LMNATSHR | |
| SCHEMBL6619964 | 0.76 | TDP1 (0.53) | LMNATSHR | |
| SCHEMBL8298145 | 0.70 | MMP12 (0.62) | MMP2MMP3MMP1LMNATSHR | |
| SCHEMBL8298940 | 0.69 | MMP2 (0.43) | MMP2MMP3MMP1 | |
| SCHEMBL14540430 | 0.69 | LMNA (0.39) | LMNATSHR | |
| SCHEMBL1609669 | 0.67 | TSHR (0.43) | LMNATSHR | |
| SCHEMBL8298149 | 0.67 | MMP12 (0.46) | MMP2MMP3MMP1LMNATSHR | |
| SCHEMBL1610131 | 0.66 | TDP1 (0.43) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476438-B1 | OXA- AND THIADIAZOLES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | VERNALIS R&D LTD (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2004101537-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LTD (GB) | 2004-11-25 | — | — | WO | disclosed |