Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.64 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.63 |
| ▸ | MGLL | Q99685 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10723602 | 0.91 | MGLL (0.67) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7232379 | 0.86 | HTT (0.73) | MEN1KMT2AHTTCYP2C19CYP2C9 | |
| SCHEMBL29941294 | 0.85 | HTT (0.69) | FAAHMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL17730065 | 0.85 | ADRB2 (0.65) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7242121 | 0.84 | LMNA (0.58) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL14600512 | 0.84 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7239929 | 0.84 | MGLL (0.66) | MEN1KMT2AALDH1A1CYP2C19CYP2C9 | |
| SCHEMBL9633280 | 0.84 | HPGD (0.64) | MEN1KMT2AHTTMGLLHPGD | |
| SCHEMBL10719972 | 0.83 | HTT (0.78) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL5789068 | 0.82 | MGLL (0.58) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166603-B2 | Dihydropyrimidone inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB CO. (US) | 2007-01-23 | — | — | US | disclosed |
| WO-2005009392-A2 | DIHYDROPYRIMIDONE INHIBITORS OF CALCIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |