Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103609 | 0.85 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2KDM4EBRD4L3MBTL1 | |
| SCHEMBL8301712 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KDM4EBRD4L3MBTL1 | |
| SCHEMBL8097066 | 0.75 | SLC6A1 (0.57) | ALDH1A1L3MBTL1 | |
| SCHEMBL13804381 | 0.73 | KDM4E (0.63) | ALDH1A1SMN1; SMN2KDM4EL3MBTL1ATM | |
| SCHEMBL8438204 | 0.73 | KDM4E (0.63) | ALDH1A1SMN1; SMN2KDM4EL3MBTL1ATM | |
| SCHEMBL14874211 | 0.73 | KDM4E (0.63) | ALDH1A1SMN1; SMN2KDM4EL3MBTL1ATM | |
| Hydrochloric Acid SCHEMBL28558936 | 0.71 | KDM4E (0.61) | ALDH1A1SMN1; SMN2KDM4EL3MBTL1ATM | |
| SCHEMBL20502983 | 0.71 | KDM4E (0.51) | ALDH1A1SMN1; SMN2KDM4EL3MBTL1ATM | |
| SCHEMBL1899356 | 0.71 | CA12 (0.50) | CHRM5CHRM1SMN1; SMN2FKBP1AL3MBTL1 | |
| SCHEMBL3985142 | 0.71 | HRH3 (0.46) | ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | disclosed |