Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.56 |
| ▸ | PLAU | P00749 | 2/20 | 0.54 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL795861 | 0.75 | ALDH1A1 (0.64) | PTGS2EGFRHSD17B10GFERP4HTM | |
| SCHEMBL23447714 | 0.75 | KMT2A (0.73) | BCL2L1MCL1PTGS2EGFRERBB2 | |
| SCHEMBL8768073 | 0.74 | NPC1 (0.66) | RAPGEF3HSD17B10LMNASMN1; SMN2MEN1 | |
| SCHEMBL29869451 | 0.73 | KDM4E (0.62) | PLAUHSD17B10LMNAHPGDSMN1; SMN2 | |
| SCHEMBL21679476 | 0.73 | KDM4E (0.62) | PLAUHSD17B10LMNAHPGDSMN1; SMN2 | |
| SCHEMBL9175525 | 0.73 | KAT6A (0.76) | BCL2L1MCL1PTGS2EGFRPTGS1 | |
| SCHEMBL29644482 | 0.72 | KAT6A (0.73) | BCL2L1MCL1KAT6AFLT1FLT4 | |
| SCHEMBL10745409 | 0.72 | GAA (0.59) | BCL2L1MCL1PTGS2EGFRERBB2 | |
| SCHEMBL15766090 | 0.72 | P4HTM (0.51) | PLAURAPGEF3PTGS2PTGS1HSD17B10 | |
| SCHEMBL28698398 | 0.71 | PTGS2 (0.71) | BCL2L1MCL1PTGS2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966437-A1 | 5-AROYLNAPHTHALENE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998032732-A1 | 5-AROYLNAPHTHALENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |