Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 12/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.58 |
| ▸ | HTR1B | P28222 | 9/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296828 | 0.95 | DRD2 (0.56) | DRD2SLC6A4HTR1DADRA1DHTR1B | |
| SCHEMBL8299563 | 0.92 | HTR1D (0.66) | DRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8303265 | 0.90 | HTR1D (0.52) | DRD2SLC6A4HTR1DADRA1DHTR1B | |
| SCHEMBL8297273 | 0.87 | HTR1D (0.62) | DRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8296910 | 0.85 | HTR1D (0.49) | DRD2SLC6A4HTR1DADRA1DHTR1B | |
| SCHEMBL8296229 | 0.84 | DRD2 (0.54) | DRD2SLC6A4HTR1DADRA1DHTR1B | |
| SCHEMBL8303616 | 0.84 | HTR1D (0.59) | DRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8299590 | 0.80 | DRD2 (0.51) | DRD2SLC6A4HTR1DADRA1DHTR1B | |
| SCHEMBL8303625 | 0.79 | HTR1D (0.56) | DRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8299251 | 0.77 | DRD2 (0.73) | DRD2SLC6A4HTR1DADRA1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1223650-A | Piperidines and pyrrolidines | MERCK PATENT GMBH (DE) | 1999-07-21 | — | — | CN | disclosed |
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |