Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | HTR1D | P28221 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299590 | 0.95 | DRD2 (0.51) | DRD2SLC6A4MEN1HTTKMT2A | |
| SCHEMBL8296251 | 0.93 | OPRM1 (0.53) | DRD2SLC6A4MEN1HTTKMT2A | |
| SCHEMBL7845970 | 0.88 | KMT2A (0.58) | DRD2MEN1HTTKMT2AADRA1D | |
| SCHEMBL8297198 | 0.88 | HSD11B1 (0.53) | DRD2MEN1HTTKMT2AHTR7 | |
| SCHEMBL8522680 | 0.86 | MEN1 (0.50) | DRD2MEN1HTTKMT2AKCNH2 | |
| SCHEMBL8300248 | 0.84 | DRD2 (0.60) | DRD2SLC6A4HTTADRA1DHTR2A | |
| SCHEMBL8301940 | 0.83 | DRD2 (0.61) | DRD2SLC6A4ADRA1DADRA1BHTR2A | |
| SCHEMBL8298950 | 0.82 | MEN1 (0.47) | DRD2SLC6A4MEN1HTTKMT2A | |
| SCHEMBL8298661 | 0.81 | MEN1 (0.50) | SLC6A4MEN1HTTKMT2AKCNH2 | |
| SCHEMBL7843427 | 0.81 | MEN1 (0.52) | SLC6A4MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1223650-A | Piperidines and pyrrolidines | MERCK PATENT GMBH (DE) | 1999-07-21 | — | — | CN | disclosed |
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |