Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27334025 | 0.86 | CYP3A4 (0.36) | MAPTCYP3A4 | |
| SCHEMBL10474713 | 0.83 | CHRM2 (0.37) | POLBMAPTCYP3A4 | |
| SCHEMBL31078958 | 0.79 | DPP4 (0.42) | GBA2LMNAPOLBSMN1; SMN2DPP4 | |
| SCHEMBL15715693 | 0.76 | GBA2 (0.47) | GBA2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL27524171 | 0.75 | GAA (0.36) | LMNASMN1; SMN2DPP4MAPTCYP3A4 | |
| SCHEMBL17154832 | 0.75 | LMNA (0.43) | GBA2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL28383221 | 0.72 | SMN1; SMN2 (0.43) | GBA2LMNAPOLBSMN1; SMN2DPP4 | |
| SCHEMBL4632458 | 0.71 | SMN1; SMN2 (0.42) | GBA2LMNAPOLBSMN1; SMN2DPP4 | |
| SCHEMBL6819738 | 0.71 | GBA2 (0.45) | GBA2LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL6052893 | 0.71 | GBA2 (0.45) | GBA2LMNAPOLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658545-B1 | Decahydro-isoquinoline derivatives | LILLY CO ELI (US) | 1999-09-29 | — | — | EP | disclosed |
| EP-0383504-B1 | Decahydro isoquinoline derivatives, process for their preparation and use as medicines | LILLY CO ELI (US) | 1995-07-19 | — | — | EP | disclosed |
| EP-0658545-A1 | Decahydro-isoquinoline derivatives | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |
| EP-0383504-A2 | Decahydro isoquinoline derivatives, process for their preparation and use as medicines | ELI LILLY AND COMPANY (US) | 1990-08-22 | — | — | EP | disclosed |