SCHEMBL8300288

SCHEMBL8300288

Cn1nc(-c2c(F)cccc2Cl)nc1-c1ccc(CO)cc1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 1/20 0.37
HSD11B1 P28845 2/20 0.36
KMT2A Q03164 2/20 0.36
ATM Q13315 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
PDE2A O00408 3/20 0.35
MAPK14 Q16539 3/20 0.35
ABL1 P00519 1/20 0.35
EGFR P00533 1/20 0.35
PDGFRB P09619 1/20 0.35
KIT P10721 1/20 0.35
FGFR1 P11362 1/20 0.35
SRC P12931 1/20 0.35
PDGFRA P16234 1/20 0.35
LMNA P02545 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
P2RX7 Q99572 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8876219 0.90 CRHR1 (0.40) CRHR1HSD11B1KMT2AATMPDE2A
SCHEMBL8878103 0.88 CRHR1 (0.41) CRHR1HSD11B1KMT2AATMSMN1; SMN2
SCHEMBL8875632 0.86 HSD11B1 (0.39) CRHR1HSD11B1PDE2A
SCHEMBL8942539 0.85 NR1H2 (0.44) KMT2AATMSMN1; SMN2PDE2ALMNA
SCHEMBL8304433 0.85 HSD11B1 (0.51) CRHR1HSD11B1KMT2APDE2ALMNA
SCHEMBL8875250 0.84 HSD11B1 (0.42) CRHR1HSD11B1KMT2ASMN1; SMN2
SCHEMBL8303712 0.78 PDE2A (0.38) CRHR1HSD11B1SMN1; SMN2PDE2ALMNA
SCHEMBL8875200 0.78 F7 (0.38) HSD11B1KMT2ALMNAMAPK1
SCHEMBL8942480 0.78 NR1H2 (0.44) KMT2AATMSMN1; SMN2PDE2ALMNA
SCHEMBL8298161 0.78 HSD17B2 (0.39) KMT2AATMSMN1; SMN2PDE2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648752-B1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-10-06 EP disclosed
US-5700824-A Triazole derivatives, insecticide, acaricide and methods thereof KUMIAI CHEMICAL INDUSTRIAL CO. LTD. (JP) 1997-12-23 US disclosed
US-5616594-A Triazole derivatives, insecticide, acaricide and methods thereof IHARA CHEMICAL INDUSTRY CO. LTD. (JP) 1997-04-01 US disclosed
EP-0648752-A1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-19 EP disclosed