Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 4/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | CES1 | P23141 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552342 | 0.88 | FAAH (0.46) | CA2CA1FFAR1MGLLFAAH | |
| SCHEMBL8301348 | 0.87 | CA1 (0.40) | CA2CA1MGLL | |
| SCHEMBL27525477 | 0.85 | CA2 (0.54) | CA2CA1FFAR1FFAR4MGLL | |
| SCHEMBL8552942 | 0.80 | CA2 (0.49) | CA2CA1FFAR1FFAR4MGLL | |
| SCHEMBL8555026 | 0.75 | CA2 (0.44) | CA2CA1LMNA | |
| SCHEMBL23291910 | 0.74 | CA2 (0.69) | CA2CA1FFAR1 | |
| SCHEMBL8441263 | 0.72 | CA2 (0.53) | CA2CA1FFAR1MGLLFAAH | |
| SCHEMBL8077441 | 0.72 | CA2 (0.53) | CA2CA1FFAR1MGLLFAAH | |
| SCHEMBL27525475 | 0.72 | CA2 (0.52) | CA2CA1 | |
| SCHEMBL11669981 | 0.71 | TAAR1 (0.46) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1222907-A | Azetidinone derivatives for treatment of atheroscleroses | SMITHKLINE BEECHAM PLC (GB) | 1999-07-14 | — | — | CN | disclosed |
| EP-0915843-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSES | SMITHKLINE BEECHAM PLC (GB) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997041098-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | disclosed |