Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300371 | 0.88 | CA2 (0.41) | FAAHCES1MGLLCA2CA1 | |
| SCHEMBL8301348 | 0.87 | CA1 (0.40) | MGLLCA2CA1 | |
| SCHEMBL8077441 | 0.84 | CA2 (0.53) | FAAHCES1MGLLMAPTRXFP1 | |
| SCHEMBL8441263 | 0.84 | CA2 (0.53) | FAAHCES1MGLLMAPTRXFP1 | |
| SCHEMBL8007555 | 0.82 | CA2 (0.54) | FAAHCES1MGLLCA2CA1 | |
| SCHEMBL8551008 | 0.79 | CA2 (0.48) | FAAHCES1MGLLMAPTRXFP1 | |
| SCHEMBL28006935 | 0.79 | ALDH1A1 (0.47) | MAPTRXFP1CA2CA1CA9 | |
| SCHEMBL11516805 | 0.77 | SIGMAR1 (0.56) | MAPTRXFP1 | |
| SCHEMBL4625553 | 0.77 | CA2 (0.55) | FAAHCES1CA2CA1CA9 | |
| SCHEMBL3767944 | 0.74 | CA1 (0.59) | FAAHCES1CA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |