Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297268 | 0.94 | DRD4 (0.56) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL8441064 | 0.89 | DRD4 (0.56) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL17731134 | 0.86 | DRD4 (0.67) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL7476441 | 0.81 | LMNA (0.64) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL8296404 | 0.80 | DRD4 (0.60) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL8304361 | 0.80 | MEN1 (0.61) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL8299569 | 0.77 | DRD4 (0.56) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL3454062 | 0.77 | ALDH1A1 (0.73) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL4003996 | 0.76 | DRD4 (0.69) | DRD4SMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL4003794 | 0.75 | DRD4 (1.00) | DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1223650-A | Piperidines and pyrrolidines | MERCK PATENT GMBH (DE) | 1999-07-21 | — | — | CN | disclosed |
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |