Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | DRD4 | P21917 | 7/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17731134 | 0.89 | DRD4 (0.67) | LMNASMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL8216077 | 0.82 | DRD2 (0.59) | LMNADRD2ALDH1A1 | |
| SCHEMBL7465842 | 0.82 | DRD4 (0.46) | DRD4DRD2DRD3 | |
| SCHEMBL8300501 | 0.81 | DRD4 (0.60) | LMNASMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL7476763 | 0.81 | NPC1 (0.54) | LMNASMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL7474955 | 0.80 | ALDH1A1 (0.66) | LMNASMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL8581205 | 0.79 | CCR2 (0.47) | DRD2 | |
| SCHEMBL17730978 | 0.77 | DRD2 (0.68) | LMNASMN1; SMN2DRD4DRD2DRD3 | |
| SCHEMBL22791636 | 0.77 | ALDH1A1 (0.48) | LMNASMN1; SMN2DRD4REV1HTT | |
| SCHEMBL4003794 | 0.76 | DRD4 (1.00) | DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |