Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29876097 | 0.86 | MAOA (0.44) | ACHEBCHEMAOAMAOB | |
| SCHEMBL28792227 | 0.86 | MAOA (0.44) | ACHEBCHEMAOAMAOB | |
| SCHEMBL8300351 | 0.82 | SLC6A2 (0.59) | QDPRACHEBCHESLC6A2SLC6A4 | |
| SCHEMBL8300839 | 0.79 | ASAH1 (0.37) | QDPRACHEBCHEPLGCDK1 | |
| SCHEMBL8290868 | 0.78 | CHRM3 (0.41) | CHRM3ASAH1 | |
| SCHEMBL9910974 | 0.77 | ACHE (0.63) | ACHEBCHESLC6A2SLC6A4CHRM2 | |
| SCHEMBL8300836 | 0.77 | ASAH1 (0.45) | ACHEBCHECHRM2CHRM4CHRM5 | |
| SCHEMBL8290869 | 0.77 | ACHE (0.46) | ACHEBCHESLC6A2SLC6A4CHRM2 | |
| Butane SCHEMBL8292425 | 0.75 | USP2 (0.40) | ACHEBCHESLC6A2SLC6A4ASAH1 | |
| SCHEMBL6603922 | 0.75 | MAOA (0.38) | ACHEBCHEMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637586-B1 | 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)-benzofuran-7-carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors | HOECHST MARION ROUSSEL INC (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5708007-A | ACETYLCHOLINESTERASE INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0637586-A1 | 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-02-08 | — | — | EP | disclosed |