Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 5/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300989 | 0.79 | QDPR (0.45) | ASAH1CDK4CCND1CDK1CDK2 | |
| SCHEMBL8292427 | 0.78 | KDM4E (0.39) | ASAH1FAAHNAAAACHEKDM4E | |
| SCHEMBL8297441 | 0.76 | ASAH1 (0.37) | ASAH1FAAHNAAACDK4CCND1 | |
| SCHEMBL8300836 | 0.75 | ASAH1 (0.45) | ASAH1FAAHNAAAACHEBCHE | |
| SCHEMBL8290868 | 0.74 | CHRM3 (0.41) | ASAH1KDM4ECHRM3CYP1A2 | |
| SCHEMBL8290869 | 0.73 | ACHE (0.46) | ASAH1ACHEBCHEKDM4ECHRM1 | |
| SCHEMBL8290905 | 0.73 | BCHE (0.45) | ACHEBCHEPLGKDM4EHTR2C | |
| SCHEMBL8300351 | 0.73 | SLC6A2 (0.59) | ACHEBCHEKDM4EQDPRSLC6A2 | |
| SCHEMBL8292426 | 0.73 | HPGD (0.42) | ASAH1ACHEKDM4ESLC6A2SLC6A4 | |
| Butane SCHEMBL8292425 | 0.71 | USP2 (0.40) | ASAH1ACHEBCHEKDM4ESLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637586-B1 | 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)-benzofuran-7-carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors | HOECHST MARION ROUSSEL INC (US) | 1999-06-02 | — | — | EP | claimed |