Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.57 |
| ▸ | WNT3A | P56704 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | EDNRB | P24530 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823544 | 0.90 | RAB9A (0.68) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL5823399 | 0.84 | CTNNB1 (0.57) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL4841835 | 0.84 | SRD5A2 (0.56) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL7532873 | 0.83 | SRD5A2 (0.69) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL4825307 | 0.81 | RAB9A (0.64) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL4823371 | 0.81 | CTNNB1 (0.78) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL4821161 | 0.80 | CTNNB1 (0.61) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL15979976 | 0.78 | CTNNB1 (0.78) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL26624014 | 0.78 | KMT2A (0.72) | RAB9ANPC1MAPTCTNNB1WNT3A | |
| SCHEMBL1375270 | 0.78 | KMT2A (0.68) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929106-A | VASODILATOR; HYPOTENSIVE AGENT | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0768878-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-02-17 | — | — | EP | disclosed |
| US-5736564-A | DIHYDROISOINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-07 | — | — | US | disclosed |
| EP-0768878-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-04-23 | — | — | EP | disclosed |
| WO-1995035107-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-28 | — | — | WO | disclosed |