Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.68 |
| ▸ | NPC1 | O15118 | 6/20 | 0.68 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.59 |
| ▸ | WNT3A | P56704 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4825307 | 0.91 | RAB9A (0.64) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8301109 | 0.90 | RAB9A (0.61) | RAB9ANPC1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL4821161 | 0.89 | CTNNB1 (0.61) | RAB9ANPC1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL4823371 | 0.87 | CTNNB1 (0.78) | RAB9ANPC1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL4824941 | 0.85 | SRD5A2 (0.82) | RAB9ANPC1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL26624014 | 0.84 | KMT2A (0.72) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15979976 | 0.84 | CTNNB1 (0.78) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5072119 | 0.83 | KMT2A (0.69) | RAB9ANPC1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL5823399 | 0.82 | CTNNB1 (0.57) | RAB9ANPC1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL4841835 | 0.82 | SRD5A2 (0.56) | RAB9ANPC1SRD5A2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119433-A1 | SYNTHESIS OF BIARYL KETONES AND BIARYL DIKETONES VIA CARBONYLATIVE SUZUKI-MIYAURA COUPLING REACTIONS CATALYZED BY BRIDGED BIS(N-HETEROCYCLIC CARBENE)PALLADIUM(II) CATALYSTS | KING FAHD UNIVERSITY OF PETROLEUM & MINERALS (SA) | 2022-04-21 | — | — | US | disclosed |
| US-11192912-B1 | Synthesis of biaryl ketones and biaryl diketones via carbonylative Suzuki-Miyaura coupling reactions catalyzed by bridged bis(N-heterocyclic carbene)palladium(II) catalysts | KING FAHD UNIVERSITY OF PETROLEUM & MINERALS (SA) | 2021-12-07 | — | — | US | disclosed |
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | RAB9A 4576/4885NPC1 789/4885SRD5A2 270/4885 |
| US-11192912-B1 | Synthesis of biaryl ketones and biaryl diketones via carbonylative Suzuki-Miyaura coupling reactions catalyzed by bridged bis(N-heterocyclic carbene)palladium(II) catalysts | PDK2, PDK3, BCKDK | RAB9A 2099/4885NPC1 3871/4885SRD5A2 1927/4885 |
| US-20220119433-A1 | SYNTHESIS OF BIARYL KETONES AND BIARYL DIKETONES VIA CARBONYLATIVE SUZUKI-MIYAURA COUPLING REACTIONS CATALYZED BY BRIDGED BIS(N-HETEROCYCLIC CARBENE)PALLADIUM(II) CATALYSTS | PDK2, PDK3, BCKDK | RAB9A 2099/4885NPC1 3871/4885SRD5A2 1927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.